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KMID : 1234920150150020068
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Journal of Korean Oriental Association for Study of Obesity
2015 Volume.15 No. 2 p.68 ~ p.74
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Effects of Traditional Chinese Herbal Medicine Shengmai-San and Pyungwi-San on Gastrointestinal Motility in Mice
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Lee Min-Cheol
Park Jin-Ryeong
Sim Ji-Hwan
Ahn Tae-Seok
Kim Byung-Joo
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Abstract
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Objectives: The purpose of this study was to investigate the effects of Shengmai-san and Pyungwi-san, a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice.
Methods: The in vivo effects of Shengmai-san and Pyungwi-san on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally.
Results: In normal Institute of Cancer Research mice, ITRs were significantly and dose- dependently increased by Shengmaisan (0.01∼1 g/kg) and Pyungwi-san (0.01∼1 g/kg). The ITRs of acetic acid induced peritoneal irritation model and streptozotocin-induced diabetic model mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by Shengmai-san (0.01∼1 g/kg) and Pyungwi-san (0.01∼1 g/kg).
Conclusions: These results suggest that both Shengmai-san and Pyungwi-san are a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.
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KEYWORD
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Gastrointestinal disease, Shengmai-san, Pyungwi-san, Gastrointestinal motility, Gastrointestinal tract, Intestinal transit rate
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